Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high
Abstract Edge-to-cloud continuum connects and extends the calculation from edge side via network to cloud platforms, where diverse workflows go back and forth, getting executed on scheduled calculation resources.To better utilize the calculation resources from all sides, workflow offloading problems have been investigating lately.Most works focus o
Paenibacillus larvae bacterium is known to be the causative agent of American foulbrood (AFB), a widespread, highly contagious and fatal disease in honey bees (Apis mellifera).There are four genotypes of Paenibacillus larvae that are named after their enterobacterial repetitive consensus (ERIC), and a tsc apparel houston fifth ERIC genotype has rec
BackgroundThe World Health Organization recommends that treatment of depression in low and middle-income countries with a scarcity of psychiatrists could be done in primary care and should include prescription of antidepressant medications for moderate and severe depression.Little is known, however, about the actual practices of antidepressant pres
Dyes are generally defined as an aromatic organic compound which shows an affinity towards the substrate to which they are being applied.The presence of dyes in wastewater samples at any level where to buy powdered food coloring is not safe for human.The presence of dyes in wastewater that being discharged from fabrics industry must be analyzed.Hen